Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells.

Sci Rep · 2023 · PMC10167355 · PMID 37156796

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highly significantno p-value reported

7 and Figure S44 ESI compounds 8t, 8k , and 8m displayed a highly significant apoptotic activity when administered at their specific IC 75 s, as waited for compounds able to inhibit MDM2 protein.

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