Flurbiprofen inhibits heme induced NLRP3 inflammasome in Berkeley sickle cell disease mice.

Front Pharmacol · 2023 · PMC10171431 · PMID 37180702

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highly significantno p-value reported

However, the group, where ATP was used as a second signal displayed a highly significant suppression of NLRP3 inflammasome at both the dose of 10 and 20 mg/kg which was evident by the reduced release of IL-1β in the peritoneal lavage ( Figure 5D ).

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