Brain region dependent molecular signatures and myelin repair following chronic demyelination.

Front Cell Neurosci · 2023 · PMC10171432 · PMID 37180951

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3 weeks samples revealed highly significant upregulation of genes associated with myelinating oligodendrocytes, including Mag, Mbp , tight-junction claudins ( Cldn14, Cldn11 ), gap-junction connexin-47 ( Gjc2 ) and connexin-32 ( Gjb1 ), Pdlim2, lysophosphatidic acid receptor 1 (Lpar1), fatty acid hydroxylase (Fa2h), and gelsolin (Gsn) ( Figure 3B , and Supplementary Table 1 ).

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