Long-Term Host Immune Modulation Following Tisagenlecleucel Administration in Patients with Diffuse Large B-Cell Lymphoma and B-Lineage Acute Lymphoblastic Leukemia.

A constant increase in intracellular production was observed in CD3, CD3/CD4, and CD3/CD8 cells, which became highly significant already at T3d for IFNγ ( p < 0.05) and at T7d for TNFα ( p < 0.005), and increased further at later time points ( Figure 4 A,B).

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