4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A.

Indeed, we found a highly significant reduction of green fluorescence in NCCR reporter transduced MKL-1 cells upon PHT treatment, suggesting repression of MCPyV early gene transcription, while late gene transcription showed a slight, but statistically not significant, increase ( Figure 1 e).

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