Activation of the Mechanosensitive Ion Channels Piezo1 and TRPV4 in Primary Human Healthy and Osteoarthritic Chondrocytes Exhibits Ion Channel Crosstalk and Modulates Gene Expression.

Int J Mol Sci · 2023 · PMC10178441 · PMID 37175575

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

Whereas the expression of all three channels investigated seemed to be slightly increased in pCH-OA compared to HC controls, there was a highly significant 5-fold difference of TRPV4 in pCH-OA (2.735 ± 0.151fold change) compared to HC (0.545 ± 0.053-fold change) in the presence of 0.1 μM Yoda1.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.