Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and Senescence.

For example, (1) there are often important differences in cellular responses between acute shRNA knockdown and stable germline knockout; (2) there may be important differences in the role of ZKSCAN3 in humans and mice; (3) there may be significant differences in transcriptional regulation of autophagy between cancer cells and non-cancer cells.

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