Biobank-scale inference of ancestral recombination graphs enables genealogical analysis of complex traits.

For instance, restricting to loss-of-function or other protein-altering WES partners for independent ARG signals not present or marginally significant in ref. 43 , five novel associations with aspartate aminotransferase are mapped to the GOT1 gene (Fig. 4f ) and four with alkaline phosphatase are mapped to ALPL (Extended Data Fig. 9e ).

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