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Global, regional, and national time trends in disability-adjusted life years, mortality, and variable risk factors of non-rheumatic calcified aortic valve disease, 1990-2019: an age-period-cohort analysis of the Global Burden of Disease 2019 study.

J Thorac Dis · 2023 · PMC10183530 · PMID 37197484

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an increasing trendno p-value reported
Regions with lower SDI levels showed no significant improvement or even an increasing trend for these indicators.

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a decreasing trendno p-value reported
Therefore, regions with higher SDI levels had higher age-standardized mortality rates overall, but most showed a decreasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.