Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the NK function in Hu-BLT mice.

In addition, there was statistically significant differences in the resistance of tumor cells to NK cell-mediated cytotoxicity dissociated from sNK+CDDP group as compared to sNK group, and both these groups had highly significant decreases in cytotoxicity when compared to those obtained from tumor alone implanted hu-BLT mice ( Figure 4E ).

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