Low- Versus High-dose Cyclophosphamide in Class III/IV Lupus Nephritis: A Retrospective Study from South Asia.

er, prospective, randomized study, compared the then standard treatment of high-dose (HD) intravenous (IV) CYC and low-dose (LD) IV CYC as remission-inducing therapy in proliferative LN.[ 4 , 5 ] The study showed no difference in the rates of renal remission, treatment failure, or severe flares and a nonsignificant trend toward a reduction in adverse effects.[ 5 ] However, the patients included in the ELNT study were predominantly white Caucasians.

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