Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti-aging klotho protein in elderly mice.

Data outcomes of this experiment, shown in Figure 2 , demonstrated that although no statistically significant differences in the content of any of the 8 solute molecules were detected, a nonsignificant trend toward levels of leptin (2A), IL‐6 (2C), IL‐1α (2E), TNF‐α (2B), IL‐1β (2F), and IGF‐1 (2D) slightly decreased in the serum of rapamycin‐treated mice versus controls was observed; moreover, a nonsignificant trend toward slightly elevated serum levels of VEGF (2G), MCP‐1 (2H) and in rapamycin‐treated mice versus control animals was also seen, as shown in Figure 2 . 3.3.

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