A positive microarray result indicating ROH showed a borderline significant negative impact on OS (Figure 2A ), while categorization of ROH in up to 25 Mb versus more than 25 Mb showed a strong and significant negative impact of ROH on both OS and AML evolution (Figure 2B,C ).
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Regions of homozygosity confer a worse prognostic impact in myelodysplastic syndrome with normal karyotype.
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