marginal significancep = 0.0609
While not significantly prognostic, histologic grades still showed a certain level of prognostic value in our study, as evidenced by the marginal significance in univariable analysis in D1 and D2 (D1: p = 0.0609 for high versus intermediate and low grade; D2: p = 0.0599 for high and intermediate versus low grade) and survival analysis for D 1+2+3 in Supplementary Fig. 5 .