P-glycoprotein efflux transporter: a key to pharmacokinetic modeling for methadone clearance in fetuses.

It is worth noting that adding the fetal liver into the fetus compartment may not be significant for methadone from ontogeny’s perspective, since some of the major metabolic enzymes (CYP2B6, CYP3A4) are still not mature in fetuses, while other enzymes such as CYP3A7 is expressed in the fetal liver that can metabolise methadone ( Wolff et al., 2005 ).

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