Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with K_ATP channel gain-of-function.

Packet frequency was the most consistently altered index of active pumping, averaging 5 min −1 in Kir6.1 wt/ wt mice, 0.4 min −1 in Kir6.1 wt/ VM mice, and 0 min −1 in Cav1.2 SM-KO mice (no packets were observed in any of the latter animals), and the differences between these groups were highly significant ( Figure 4F ).

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