Because of the small number of included small studies in our subgroup analysis and in accordance with the Cochrane Manual for Meta-Analyses, a borderline significant result such as our P value of 0.06, instead of the conventional value of 0.05, can be considered statistically significant [ 42 ].
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Long-term supplementation with 3200 to 4000 IU of vitamin D daily and adverse events: a systematic review and meta-analysis of randomized controlled trials.
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However, subgroup analysis revealed borderline significance in trials with > 100 and ≤ 100 study participants with an RR of 2.63 (95%CI: 1.30–5.30; 7 studies) and 0.80 (95%CI: 0.24–2.62; 3 studies), respectively (P interaction = 0.06).