Interleukin-6 as a marker of Huntington's disease progression: Systematic review and meta-analysis.

Although plasma IL-6 levels did not significantly differ between pre-manifest and early HD patients ( g = −0.06, 95% CI = −0.42,0.31, P = 0.76), plasma IL-6 levels were significantly increased in moderate versus pre-manifest HD patients ( g = 0.48, 95% CI = 0.11,0.85, P = 0.01) and moderate versus early HD patients ( g = 0.52, 95% CI = 0.18,0.86, P = 0.003); demonstrating an overall trend of increasing plasma IL-6 levels with HD progression ( g = 0.32, 95% CI = 0.07,0.58, P = 0.01). 3.5.

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