Barely Significant
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Comparative Study of Gabapentin, Clonidine and Placebo in Alleviating the Hemodynamic Changes Due to Tracheal Intubation and Laryngoscopy.

Cureus · 2023 · PMC10199743 · PMID 37214051

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highly significantP <0.0001actually significant
A highly significant heart rate elevation following direct laryngoscopy and endotracheal intubation was recorded in all three groups (P <0.0001), but heart rate rise duration was longest in the placebo group and of shortest duration in the clonidine group (Mean HR at 15 minutes: 80.80±15.41 in the placebo vs 65.53±12.43 in clonidine group).

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