Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau.

Analysis of similarities (ANOSIM) analysis illustrated that the J.0 M group had significantly lower R values than the GH.3 M, GH.6 M, and GH.12 M groups ( R =0.453 696, R =0.356 417, and R =0.717 596, respectively; all P =0.004 975), and there was a highly significant difference between GH.3 M and GH.6 M ( R =0.498 653, P =0.004 975), so the GH.3 M and Z.3 M groups had higher R than the other groups and resembled the apex of the parabola, while the J.0 M, GH.12 M, and Z.‍12 M groups presented the two ends of the parabola ( Fig. 4 d).

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During the one-year observation period, among the top 10 bacterial phyla, six (Proteobacteria, Acidobacteriota, Cyanobacteria, Verrucomicrobiota, Desulfobacterota, and Gemmatimonadota) showed an increasing trend in relative abundance from the J.0 M group to the GH.3 M group, followed by a decreasing trend from the GH.3 M group to GH.12 M group.

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