Nephroprotective mechanisms of Rhizoma Chuanxiong and Radix et Rhizoma Rhei against acute renal injury and renal fibrosis based on network pharmacology and experimental validation.

Differences were considered significant if p < 0 05, highly significant if p < 0 01, and very highly significant if p < 0.001. 3 Results 3.1 Active ingredients and targets of CX and DH Among 281 chemical components of CX and DH retrieved from the TCMSP database and screened based on pharmacokinetic characteristics (OB ≥ 30% and DL ≥ 0.18), 23 chemical components were included in the analyses.

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