Resistance mechanisms of tigecycline in <i>Acinetobacter baumannii</i>.

In another study, in contrast, msbA had a highly significant p value in the tigecycline-resistant group; they considered msbA mutations to be gain-of-function mutations and speculated that a possible resistance mechanism is that these mutations expand pump specificity, facilitating tigecycline efflux ( Hammerstrom et al., 2015 ).

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