When we used a continuous outcome, providing maximum power, and included the interaction term between implementation strategy and severity step, we found a marginally significant difference between arms for adherence to the ADAPT CP for patients with higher or more severe levels of anxiety and/or depression.
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Effect of core versus enhanced implementation strategies on adherence to a clinical pathway for managing anxiety and depression in cancer patients in routine care: a cluster randomised controlled trial.
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Yet we observed a highly significant difference for the main effect of anxiety/depression step on adherence, with lower adherence overall for those with greater anxiety/depression.