Effect of Lymphopenia on Tumor Response and Clinical Outcomes Following Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer.

Lung Cancer (Auckl) · 2023 · PMC10204762 · PMID 37228390

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an unexpected trendp=0.07so close (0.05 < p ≤ 0.1)

26 , 27 In RTOG 0617, dose escalation to 74 Gy compared to 60 Gy resulted in an unexpected trend towards inferior local control 61.8 → 54.3% (p=0.07) and OS 32.1 → 23% (p=0.06). 28 One potential explanation suggests that dose escalation may inhibit the host immune response by reducing populations of lymphocytes. 29 Indeed, Colton et al, and Ladbury et al suggested that the immune system could

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