Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors.

Immunooncol Technol · 2023 · PMC10205783 · PMID 37234285

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highly significantno p-value reported

This activity translates into in vivo efficacy as demonstrated by the highly significant reduction of lung fibrosis and corresponding reduction in lung collagen deposition by IOA-289 in the widely accepted mouse model of lung fibrosis, the bleomycin-induced lung injury model.

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