Epigenetic regulation of human-specific gene expression in the prefrontal cortex.

Strikingly, the genes adjacent to H3K4me3 HP gain regions showed highly significant enrichment for genes involved in myelination assembly, neuronal ensheathment, receptor clustering, and high overlap with oligodendrocyte markers (48/365 genes, BH-corrected P = 1.905 × 10 −15 ), all of which were related to myelin membrane formation and signaling transmission (Fig. 2 B; Additional file 1 : Table S7).

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