A cautionary note regarding this conclusion is that for self-administration, the 1:3 additive effect reflected results from a single monkey (318-01, see Figure 3 ), whereas for deep sedation, the average effect of the 1:9 proportion trended to supra-additivity, but did not achieve significance due to variability associated with the pregnanolone effect (see Figure 5 ).
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Behavioral effects of triazolam and pregnanolone combinations: reinforcing and sedative-motor effects in female rhesus monkeys.
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