Over 30-Fold Enhancement in DNA Translocation Dynamics through Nanoscale Pores Coated with an Anionic Surfactant.

Label-free sensing of short dsDNA fragments is highly significant for many biomedical applications. 21 , 22 For example, cell-free circulating tumor DNA as well as nucleosome DNA are naturally cut into short fragments of ∼150 bp (or less). 23 − 25 The typical translocation speed of such DNA fragments is at the order of <10 μs, 26 challenging NP sensing as high bandwidth amplifiers involve substantially increased overall noise. 27 The experiments shown in Figure 1 and Figure 2 suggest that slowing down in SDS-coated NP may be achieved without compromising NP sensing performances or a reduced capture rate.

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