Development and Validation of Blood-Based Predictive Biomarkers for Response to PD-1/PD-L1 Checkpoint Inhibitors: Evidence of a Universal Systemic Core of 3D Immunogenetic Profiling across Multiple Oncological Indications.

In that study, an EpiSwitch systemic biomarker associated with regulation of the POU2F2 locus provided highly significant binary baseline calls for benefit from treatment with Avelumab in combination with best supportive care (BSC) against the control arm of BSC alone, demonstrating a Hazard Ratio of 0.44.

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