Peptide-Functionalized and Drug-Loaded Tomato Bushy Stunt Virus Nanoparticles Counteract Tumor Growth in a Mouse Model of Shh-Dependent Medulloblastoma.

Analyzing Cyclin D1, an important regulator of cell cycle progression, we did not find significant variation in the expression levels among groups ( Figure 3 d); however, a decreasing trend in both treated groups is consistent with the lower proliferation index of PNLs MB ( Figure 1 d), suggesting that repeated administrations of the DOX-carrying NPs would be able to inhibit tumor cell proliferation also during the late stage of MB development.

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