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Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer.

ESMO Open · 2023 · PMC10220270 · PMID 37236086

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an increasing trendno p-value reported
12 Significantly, a multinational study involving Hong Kong, Taiwan, Korea and Japan 13 identified an increasing trend in early-onset (<50 years of age) colon and rectal cancers.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.