However, more recent studies have identified a decreasing trend in the use of off-label rhBMP2 usage.
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Current Trends in Recombinant Human Bone Morphogenetic Protein 2 (rhBMP2) Usage for Spinal Fusion Surgery.
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The sentences
There has been an increasing trend of rhBMP2 use in ACDF surgery from 2% in 2002 to 10.7% in 2007.