Deprescribing to optimise health outcomes for frail older people: a double-blind placebo-controlled randomised controlled trial-outcomes of the Opti-med study.

In this context, the present findings of a possible trend to worse survival in the open intervention group was not anticipated.

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There was a highly significant reduction in the total number of medicines used per participant in both intervention groups compared to the control group without an increase in the number of PRN medicines charted or administered or a significant change in Drug Burden Index ( Table 2 ).

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