A) Inhibiting caspase-dependent apoptosis may cause cells to die by necrosis or Caspase-independent apoptosis [ 77 ], B) The activity of Caspase may be significant in cytoskeletal remodelling as well as other physiological activities [ 78 ] that could be inhibited, C) Caspase inhibitors may cause defective cells to survive, leading to survival but with little functional value.
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Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury.
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