Discussion The present study describes a highly significant function of hepatocyte–osteoclast communication, where upregulation of hepatocyte SIRT2 is involved in aging-associated NF-κB p65 activation and osteoclastogenesis through sEV-LRG1.
1
—
—
Discussion The present study describes a highly significant function of hepatocyte–osteoclast communication, where upregulation of hepatocyte SIRT2 is involved in aging-associated NF-κB p65 activation and osteoclastogenesis through sEV-LRG1.