Ethambutol optic neuropathy in the extended anti-tubercular therapy regime: A systematic review.

Although the EMB dose has been maintained around 15–20 mg/kg body weight since 1965, the duration of usage has progressively increased to as long as 12–18 months.[ 9 , 19 , 24 ] EON is known to be affected by increase in both the dose and duration of EMB.[ 6 , 9 ] Some studies reported residual visual defects at the final evaluation after stopping EMB.[ 11 , 12 , 17 ] This is a worrying trend as it contradicts the previous hypothesis that EMB causes reversible EON.[ 10 , 27 ] b.

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