Consistently, single-cell RNA sequencing database also demonstrated that Pfkfb3 expression exhibited an increasing trend in the cardiac fibroblasts from mice 7, 14, and 30 days post infarction (Fig. 2 c).
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Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction.
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