Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam.

Epilepsia Open · 2023 · PMC10235584 · PMID 37026764

Europe PMC DOI

hedged sentence

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

borderline significanceP = 0.053so close (0.05 < p ≤ 0.1)

However, linear regression fit using only this subset of selected biomarkers confirmed a significant predictive value for the 2d‐S100B ( P = 0.009), 2d‐HMGB1 ( P = 0.026), (7d‐2d)‐HBGB1 ( P = 0.001), and (7d‐2d)‐TNF ( P = 0.02), whereas 2d‐TNF had borderline significance ( P = 0.053) and (7d‐2d)‐GFAP was not significant ( P = 0.185).

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