ANCA vasculitis expands the spectrum of autoimmune manifestations of activated PI3 kinase δ syndrome.

While APDS patients have wide-ranging clinical phenotypes from being asymptomatic to substantially severe ( 3 , 7 ), the overall disease burden and healthcare utilization are fairly significant often with need for multiple surgical interventions and combination of treatment modalities ( 5 , 6 ).

also in 163 other papers