4d, e , we observed that the wound closure speed and migration/invasion activity were clearly significantly suppressed by SMYD2 knockdown compared to siCont transfection, suggesting that SMYD2 knockdown effectively inhibited metastatic activity in In-H1299 cells as well as in wt-H1299 cells.
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Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis.
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