Neuroimaging glutamatergic mechanisms differentiating antipsychotic treatment-response.

Sci Rep · 2023 · PMC10238402 · PMID 37268668

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significantP = 0.06so close (0.05 < p ≤ 0.1)

Striatal region of interest analysis For the investment phase, treatment-responsive patients showed reduced caudate activations compared to control participants [ T (37) = 2.05, P < 0.05, d = 0.67], and borderline significant reductions compared to treatment-resistant patients [ T (40) = 1.9, P = 0.06, d = 0.6] (Fig. 4 B).

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highly significantno p-value reported

The integration of neurochemical and functional imaging modalities revealed highly significant associations between glutamate and reward processing differentially in treatment resistant and treatment-responsive patients, even in the absence of group differences in each modality separately.

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