34 Although multiplex immunohistochemistry revealed a highly significant difference in the distribution of immune-exhausted CD8 T cells and regulatory CD4 T cells depicting a higher degree of T cell dysfunction in HIV+ cases, transcriptomic experiments complement these findings by emphasising a greater role in the differential regulation of pro-inflammatory pathways including evidence of complement downregulation, alongside dysregulation of cytokine and chemokine pathways.
← all excerpts
Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma.
1
—
—