Likewise, in the Covid-19 datasets, the associations were much stronger for ELVAR, marginally significant for Milo, whilst DA-seq did not achieve significance (Fig. 5g–i ).
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Cell-attribute aware community detection improves differential abundance testing from single-cell RNA-Seq data.
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To confirm this, we ran negative binomial regressions, which revealed highly significant and robust negative and positive associations for naïve and mature Cd4t cells, respectively (Fig. 3g ).