There is a borderline significance in κ-opioid receptor mRNA and prodynorphin in the dPFC and orbitofrontal cortex of alcoholics. 11 In addition, environmental factors, such as chemicals exposure, have been suggested to be related to brain development and dysfunction, despite the presence of manganese in the air, food, and water at
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Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence.
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