Barriers and facilitators to the implementation of guidelines in rare diseases: a systematic review.

Orphanet J Rare Dis · 2023 · PMC10246545 · PMID 37286999

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an increasing trendno p-value reported

Publication dates ranged from 1995 to 2021 (median 2016) with an increasing trend in publication rate when studies from 2020 and 2021 were excluded (overall reduction in research due to COVID-19 pandemic).

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