highly significantP < .001
In conclusion, the authors found a highly significant association of fibrinolytic markers, endothelial markers, and levels of coagulation (fibrinogen with a weighted mean difference of 0.43 and P < .001) with AF in AF patients compared to SR patients. 33 Another study reported a significant difference in the prothrombotic state (irregularity of blood coagulation) when patients with permanent as well as paroxysmal AF were compared to those with persistent AF or SR controls.