Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study.

Drug Saf · 2023 · PMC10252161 · PMID 37294532

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an increasing trendno p-value reported

Regarding the alternative medications, we found an increasing trend in rates of use for the indications epilepsy and bipolar diseases across the study period in most databases (i.e., DNR [Denmark], ARS [Italy], PHARMO [Netherlands] and CPRD [UK]), while the rates for migraine were mostly steady.

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