Since after cytokine treatment significant differences are not appreciable between cells, whether pre-treated or not, but an increasing trend of p62 mRNA and protein under cinnamon pre-treatment is observable, we could speculate that p62 might be mainly engaged in these regulatory pathways rather than only in the autophagic machinery.
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Digested Cinnamon (<i>Cinnamomum verum</i> J. Presl) Bark Extract Modulates Claudin-2 Gene Expression and Protein Levels under TNFα/IL-1β Inflammatory Stimulus.
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