DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.

This highly significant result was not due to a corrupt plasmid or a DNA delivery failure because nearly all E72A-regenerated livers showed near-complete reconstitution, as evidenced by cell-wide moderate-to-strong A3A immunostaining in >85–90% of hepatocytes ( Figure 2 C, right panels).

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