A high-throughput cytotoxicity screening platform reveals <i>agr</i>-independent mutations in bacteraemia-associated <i>Staphylococcus aureus</i> that promote intracellular persistence.

Strains with transposon insertions in agrA , agrC , and ausA showed a highly significant reduction in PI uptake AUC (adjusted p = 5.4 × 10 −4 , Wilcoxon rank-sum test), confirming their reported roles in affecting bacterial cytotoxicity and validating our convergence analysis ( Figure 5F ; Blättner et al., 2016 ; Das et al., 2016 ; Laabei et al., 2021 ; Mairpady Shambat et al., 2016 ).

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